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Of these, 23,424 passed quality control (Supplemental Figure 1), of which 23,060 (98.4%) represented neurons (Supplemental Figure 2), consistent with the known restriction of LepRb expression to neurons in the hypothalamus and the expression of Cre recombinase from the LepRb-specific Lepr exon in Lepr Cre [20]
The same goes for Wegovy
It is worth adding at the outset, however, that an important element of successful therapy is the proper selection of the method of administration of the peptide
Additionally, glucagon appears to reduce food intake through mechanisms distinct from GLP-1, providing a second independent appetite suppression pathway
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