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The agency will then evaluate the evidence supporting the proposed indications, dosing, manufacturing process, safety profile, labeling, and risk-management requirements

Diabetes 56 , 17611772 (2007)

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Cell death in cancer cell lines To evaluate the ability of leading candidate proteases to induce cell death via procaspase-1 and gasdermin D cleavage, we stably integrated X(PC) and X(GD), as well as catalytically inactive variants as negative controls, into cancer cell lines under doxycycline-induced expression (Fig