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Experimental investigations have reported effects on VEGFR2 phosphorylation, focal adhesion kinase (FAK) activation, ERK1/2 signaling, and nitric oxide-associated regulatory pathways

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Recent studies also identified Yes-associated protein (YAP) and transcriptional coactivator with the PDZ-binding motif (TAZ) as key mechanoresponsive factors in the Hippo pathway to transmit blood flow-induced mechanical forces into intracellular signaling to affect EC phenotypes [223]