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In fact, as well detail in a later section, liraglutide in 2016 became the first GLP-1 agonist shown to reduce cardiovascular events in a dedicated outcomes trial (LEADER) an immensely important finding that added another dimension to its therapeutic profile
Adequate hydration helps manage constipation, a common side effect of slowed gastric motility
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Beyond engaging canonical hypothalamic and hindbrain networks that control metabolic homeostasis, GLP1RAs recruit a discrete population of Glp1r -expressing neurons in the central amygdala, which selectively suppress the consumption of palatable foods by reducing dopamine release in the nucleus accumbens
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