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Improvements are not guaranteed, and joint pain may continue when cartilage damage, inflammation, or another structural condition is present

Patients without diabetes but with obesity will likely be eligible for using this medication especially if the patient is looking for a potent agent with no stimulatory adverse effects

What Id genuinely like to see, and what the field needs, is a properly conducted Phase III randomised controlled trial in fibromyalgia patients, ideally with a sub-group of people with hypermobility and EDS, using low to moderate doses and with muscle mass, GI function, and bone health as pre-specified safety endpoints

& Sullivan, J