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Another SOAT gene, SOAT1, encodes a protein that is also involved in the regulation of intracellular cholesterol concentrations
The impairment of astrocytic autophagy plasticity due to the loss of LC3B and SQSTM1 function accelerates A aggregation and increases GFAP-positive astrocytes in AD mice, thereby amplifying neuronal damage and memory deficits 13 (Fig
Attacks are agonizing, exhausting, and disruptive to the lives of these children
Li et al., 2011)
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