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Miao Z, Jiang S, Ding M, Sun S, Ma Y, Younis MR, et al
We need to keep in mind that increased brain penetrance of GLP-1R agonists might lead to a host of new side effects, such as anxiety and increased stress responses, Rinaman warned
The largest trial of ERAs, SONAR, including 2648 participants with type 2 diabetes and proteinuric CKD, demonstrated that atrasentan on top of RAS inhibition significantly lowered the risk of a doubling of serum creatinine or ESKD compared with placebo by 35% [75]
This prevents receptor desensitization and mirrors the way the body naturally regulates growth hormone
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