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The most common reasons include: Gastrointestinal side effects such as nausea, vomiting and diarrhea which are the single most frequently documented reason for stopping in large health system datasets High out of pocket cost and lack of insurance coverage particularly in individuals without diabetes Medication unavailability or pharmacy supply shortages which peaked in 2023early 2024 Perceived completion of therapy once target weight is reached or weight loss plateaus Concerns about long term safety or treatment burden of injections Many cohorts show substantial discontinuation by 3 months, with further losses by 6-9 months
The severity of nausea may be reduced by starting with lower doses and gradually titrating upward, eating smaller meals, avoiding high-fat foods, and maintaining adequate hydration
A registered dietitian nutritionist degree program should have ACEND accreditation, which ensures a level of quality and intensity in training that exceeds expectations
After removing duplicates, six abstracts were screened based on relevance, and two full texts were assessed
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