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Role of OSM and IL-1 in PAMP stimulation We have previously shown that the inflammatory cytokines IL-1, IL-1 and OSM are important drivers of NHO pathogenesis in mice and humans [15, 16, 34]

Consequently, SCFAs hold promise for glycemic control by modulating intestinal gluconeogenesis

393 Other novel targets P2Y14R, a member of the purinergic receptor family, has been shown to promote the transcription of RIPK1 through the cAMP/PKA/CREB signaling axis, thereby driving necrotic apoptosis of intestinal epithelial cells and exacerbating intestinal barrier disruption and inflammatory responses

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