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Research published in Scientific Reports demonstrates that aged mice treated with NNMT inhibitors showed approximately 40% greater grip strength compared to untreated controls, remarkably surpassing even the benefits achieved through intensive exercise alone, which produced only 20% improvement

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The system Xc- facilitates the transfer of extracellular cystine to intracellular glutamate in a 1:1 ratio, subsequently leading to the synthesis of GSH from intracellular cystine, supported by the functions of glutamatecysteine ligase (GCL) and glutathione (GSS) [64]