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For the pre-bed option, the last meal of the evening should be finished well before the dose

doi: 10.1007/s12253-017-0278-3 146

Cyanocobalamin binding to transcobalamin II triggers mast cell degranulation in histamine-sensitive individuals, producing the warmth, redness, or mild itching that appears 1530 minutes post-injection and typically resolves within 90 minutes