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Accordingly, evidence is graded in this report as: Level A (highest) : authorised product information and pivotal trial safety tables as reported in labelling (high internal validity

In real life, the practical goal is simpler than the numbers might suggest

R.et al (2012)

For example, in neurodegenerative diseases, the accumulation of misfolded proteins overwhelms the HSP system, leading to the activation of autophagy and mitophagy