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No serious adverse events related to skin sensitivity were documented, and no participants discontinued treatment solely because of this side effect
However, the full therapeutic effect for weight loss and sugar control will develop gradually over 3-6 months as the dose increases
Recent research has shown that silymarin reduces acute toxic liver injury caused by APAP by increasing hepatocyte proliferation, decreasing CYP2E1 activity and expression, and decreasing the production of toxic metabolites (Yang et al., 2022b)
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