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While Glu9 of GLP-1 formed strong and persistent hydrogen bond and van der Waals interactions with R190 2.60 , Y152 1.47 , and to a lesser extent, Y148 1.43 , the polar side chain of Gln3 in oxyntomodulin only formed weak and very transient hydrogen bonds with these residues, and van der Waals interactions only with Y148 1.43 (Movie S1, Supplementary Table 3)

Some research has also explored how PT-141 interacts with various hormonal systems and neurotransmitter pathways, making it a popular subject in neuroscience and behavioral pharmacology labs

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Similar benefits were seen with calorie restriction, suggesting that weight loss may have been a major contributing factor for these effects