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This suggests that accessibility of specific beneficial bacterial proteins, such as Amuc_1100 (see below) which is present on the outer membrane, or other compounds, is increased by pasteurization [14]
It requires careful titration, starting low to minimize nausea, then gradually increasing to a therapeutic level
NHS Note
In the phase III STEP 6 trial conducted in Japan and South Korea, semaglutide 2.4 mg resulted in a mean percentage change in body weight from baseline to week 68 of -13.2% (standard error [SE] 0.5), compared with -2.1% (SE 0.8) achieved with placebo, corresponding to a between-group difference of -11.1% (95% confidence interval [CI], -12.9 to -9.2) using the treatment policy estimand
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