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These include capsaicin (reduces the level of a pain transmitter called Substance P), SAMe or S-adenosylmethionine (an endogenous compound that stimulates cartilage production), and anthocyanidins (an antioxidant that prevent the degradation of collagen)

Administration of spironolactone, a selective MR antagonist, counteracted stress-induced mGlu2 suppression and the related development of depressive-like behavior, implicating rapid action of glucocorticoids via a receptor that is known to modulate glutamate release [20]

But there is no consensus on whether this type of translocation occurs via paracellular or transcellular pathways (Shirasaka et al., 2022)

The benefit of improved therapeutic effect with higher doses should be weighed against the possibility of a greater incidence of adverse reactions