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Gastroenterology 2024;167(2):402404.e3

Free radicals that are a result of the oxidative stress we see in hypothyroidism and Hashimotos are an important cause of mitochondrial damage

10.1155/2013/957947 36 HowitzK

These osteoclast defects appear to be cell-autonomous, as they could be recapitulated by culturing osteoclast precursors from the global IGF-I KO mice, which showed reduced ability to differentiate into mature osteoclasts (65)