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A 2023 peer-reviewed study in the Journal of Cosmetic Dermatology confirmed that GHK-Cu and hyaluronic acid together produce a synergistic effect on collagen IV upregulation, enhancing anti-aging outcomes beyond what either ingredient achieves alone

GHK-Cu is a copper-binding peptide that up-regulates collagen and elastin synthesis while down-modulating matrix metalloproteinases (MMPs), driving skin remodeling and connective-tissue repair