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Tsai and colleagues note that even though meds like Wegovy and Zepbound are effective in helping people shed pounds, the drugs' "high cost and high rates of gastrointestinal adverse effects can lead to treatment cessation and subsequent weight regain." Demand for weight-loss meds has also outstripped supply, so it's possible that the number of weight-loss surgery patients may rise again if "ongoing national shortages" of GLP-1s continue, the research team added
On the other hand, insulin promotes pancreatic cancer initiation and sustains PDA development by eliciting tumorigenic inflammation, regulating lipid and glucose metabolic reprogram, overcoming apoptosis through the crosstalk with IGF-1, stimulating cancer metastasis, and activating tumor microenvironment formation (inflammation, fibrosis, and angiogenesis)
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