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Clinical Trial Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice

Therefore, CMS responded by extending the Bridge from six months to 18

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Among the main obstacles are the complicated interactions between genetic and environmental variables, poor adherence to lifestyle modifications, and restricted access to therapies, especially in low- and middle-income countries