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Connecting insufficient sleep and insomnia with metabolic dysfunction
It is believed that protein and micronutrient deficiencies in early childhood impair pancreatic development and -cell function, ultimately reducing insulin secretion through pathways involving oxidative stress-induced -cell apoptosis and epigenetic alterations in key transcriptional regulators of insulin gene expression, such as PDX1 and MafA [144,145,146] The recognition of Type 5 diabetes highlights undernutrition as an independent mechanistic driver of metabolic disease and reinforcing the need for nutritional and context-specific therapeutic strategies in affected populations
Drge W: Aging-related changes in the thiol/disulfide redox state: implications for the use of thiol antioxidants
If you are weighing your options and trying to understand how these approaches compare, our guide on naltrexone versus GLP-1 for alcohol use disorder lays out the differences in plain terms
