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Supplementation with an olive oil rich diet (G1-P21) [132], a highly palatable food diet in females (P28-65) [133], a highly palatable food diet in both sexes (P20-84) [134] or a HFD in males (P20-84) [135] reversed the POS-induced depressive-like behavior in the FST in males at P80-87 [132] and at W10-12 [134] and in females at P54-59 [133], and in the SPT in males at P34-84 [135]

A consistent model goes with ligation leading to vessel injury, exposure of tissue factors, stasis, thrombosis, hemodynamic changes, arterial hypotension, and in particular, venous hypertension, which approximates values over 20 mm Hg in the inferior caval vein, thereby being roughly four times higher than those in normal rats

In summary, modulation of lactate metabolism represents a promising avenue for managing ferroptosis in disease

they amplify each others benefits