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To assess the half maximal inhibitory concentration (IC50) of FOXO4-DRI on the serum limitation-induced senescent fibroblast and the non-senescent control fibroblast, the fibroblast viability in the 2% FBS induced senescent fibroblast and 10% FBS cultured non-senescent control fibroblast with increasing concentrations of FOXO4-DRI was detected, and the cell viability curves were showed in Supplementary Fig

Results PQQ protects against myocardial hypertrophy and fibrosis in a TAC-induced mouse model system Initially, a C57BL/6 mouse model of myocardial hypertrophy was established by using previously published protocols to perform the TAC procedure, with a subset of these mice being treated using PQQ (Figure 1A)

RoseSMelnykSPavlivOBaiSNickTGFryeREet al

Reduces Chronic Inflammation Inflammation is one of the most common root causes of pain and disease