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In anesthetized rats, we created the colocutaneous fistula at 5 cm from the anus, colon defect of 5 mm, and skin defect of 5 mm
Moreover, a comparison of the number of animals with unhealed defects (all controls) or healed defects (complete bony continuity across the defect site) showed that besides pentadecapeptide intramuscular application for 14 days (i.e., local application of bone marrow or autologous cortical graft), also following other pentadecapeptide BPC-157 regimens (local application, or intermittent intramuscular administration), the number of animals with healed defect was increased
Data Availability No datasets were generated or analysed during the current study
Endothelial migration and angiogenesis research uses the blend to characterise the combined effects of TB-500's direct actin-sequestering activity on endothelial cell migration and BPC-157's polypharmacology on angiogenic factor expression
