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Office of Dietary Supplements, US National Institutes of Health
13 (Suppl 13): S33S37
Mechanistic and receptor expression considerations The review highlights that GLP-1R expression in peripheral immune and non-immune tissues is very low and technically challenging to detect, necessitating the use of validated multimodal methods
At therapeutic IV doses (often 2550 g in oncology and critical-care research), studies report improvements in inflammation markers, oxidative stress, and quality of life in advanced cancer and sepsis, although evidence is strongest for adjunctive rather than standalone use
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