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Emerging approaches advocate for a paradigm shift, integrating multimodal biomarkers, such as neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), tau protein (Tau), with in vivo imaging (fMRI, and PET), AI-driven patient stratification and adaptive trial designs

A full-thickness skin wound with a diameter of 6 mm was created on the dorsal region of each mouse

4.3 Temporal dynamics The temporal dynamics of BBB disruption are critically important for determining treatment timing and developing intervention strategies, which has led to the classification of ischemic stroke into acute and subacute phases

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