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[5] The most scientifically cautious interpretation is not that broad off-target inhibition has been proven, but that broader non-target effects cannot be excluded when experiments use high concentrations, long exposure windows, sensitive cell systems, or designs lacking orthogonal NNMT validation
[115] Other cobalamin-requiring methyltransferase enzymes are also known in bacteria, such as Me-H 4 -MPT, coenzyme M methyltransferase
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