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Since the mean/median duration for each of these studies was 100,000 patients prescribed a GLP-1RA, after propensity matching, there was reduced risk for PDAC during a 5-year observation period for GLP-1RA users compared to six categories of commonly used diabetes medication classes 44

In addition, pretreatment with GHK-Cu was able to reduce i-NOS expression, consistent with the repression of NF-B pathway activation

The question of whether semaglutide directly causes pancreatitis remains an area of ongoing investigation, with current evidence suggesting a possible association rather than a confirmed causal relationship