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Chronic exposure has been associated with: Liver stress Immune suppression Increased inflammatory burden (14) Trichothecenes Often associated with Stachybotrys chartarum , trichothecenes can: Inhibit protein synthesis Disrupt mucosal immunity Intensify inflammatory signaling (15) Gliotoxin Produced by certain Aspergillus species, gliotoxin has immunosuppressive effects and may impair macrophage function and immune clearance (16)

The study confirmed that brain homogenates could also be effectively used to evaluate DSIPs influence on mitochondrial functional state, with DSIP and Deltaran showing comparable activities in both isolated mitochondria and brain homogenates

TABLE 1 Strength of association between variables for individual antioxidant enzymes

Marine, J