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These are hormones that are normally released after eating and help insulin be secreted from the pancreas
Unlike conventional occupancy-driven inhibitors, PROTACs facilitate the selective degradation of target proteins, thereby offering an opportunity to achieve sustained and isoform-specific knockdown
But the SELECT trial hinted that theres more going on
In 1982, they published a paper in the Proceedings of the National Academy of Sciences (PNAS), revealing that the glucagon precursor gene actually encodes three peptides-glucagon and two new hormones expressed in the intestine
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