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Protein kinase C restricts transport of carnitine by amino acid transporter ATB0,+ apically localized in the bloodbrain barrier

This metabolic adaptation can be relevant in triple-negative breast cancers (those lacking ERs, PRs and HER2, which constitute approximately a quarter of breast tumours) that express xCT, which exhibit increased levels of ROS induced by decreased glutamate levels upon glutamine scarcity

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