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Pros: Naturally occurring in the body, giving it a favorable long-term safety profile compared to many synthetic peptides Backed by decades of published research on collagen synthesis, wound healing, and antioxidant activity Available in both topical (cosmetic-legal) and injectable forms depending on desired intensity Cons: Injectable/research-grade product is not standardized or quality-controlled the way pharmaceuticals are, so purity varies significantly by vendor High topical concentrations can cause skin irritation, and there is limited long-term human trial data for injectable use Side Effects: Topical use is generally well tolerated, with occasional mild redness, tingling, or dryness at the application site
Several reasons may explain the observation that the mean treatment difference was 12.5% in STEP 1 and 8.7% in SELECT
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