Sangouni AA, Zadeh SH, Mozaffari-Khosravi H, Hosseinzadeh M
Individuals with the following cardiac conditions should exercise caution and may require thorough cardiovascular assessment before treatment: Uncontrolled tachyarrhythmias : Patients with poorly controlled atrial fibrillation, atrial flutter, or ventricular tachycardia may experience worsening symptoms due to the heart rate-increasing effects of these medications
Cho SG, Lee YH, Park HS, Ryoo K, Kang KW, Park J et al
Thirdly, both drugs modulate metabolic parameters, such as blood pressure, and uric acid, and hence exert multiple metabolic benefits to various organs in the body, including the heart, brain, liver, pancreas, and kidney