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Subgroup analyses across HFpEF trials evaluating neurohormonal antagonists have revealed less benefit in patients with HFpEF and the highest truly normal LVEF, suggesting the presence of disease-driving mechanisms not targeted by the respective intervention
The microbiome-derived metabolite tmao drives immune activation and boosts responses to immune checkpoint blockade in pancreatic cancer
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Whilst tirzepatide itself does not cause blood clots, patients with obesity and type 2 diabetes have inherently elevated cardiovascular risk
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