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When activated, AMPK may enhance insulin sensitivity, increase glucose uptake in skeletal muscle, suppress hepatic gluconeogenesis, and improve lipid metabolism

The goal is to make nasal sprays isotonic with nasal secretions, typically aiming for an osmolarity of 260 to 320 mOsm/kg, which corresponds to the osmotic balance naturally found in the nasal environment

Better absorption means more of it reaches liver cells where it is actually needed

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