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Funding This work was supported by the CNPq/Brazil, Bill & Melinda Gates Foundation (process 401726/2015-0 APP/Call 47/2014) and the INCT/Excitotoxicity and Neuroprotection (465671/2014-4)

However, factors like stress, pollution, poor diet, and ageing reduce glutathione levels

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For primary cell work, human skeletal muscle satellite cells, chondrocytes, and osteoblasts all express functional IGF-1R and respond robustly to IGF-1 LR3