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In animal studies, some GLP-1s have shown harmful effects on developing foetuses, which has led to caution around use in pregnancy and breastfeeding
Psychiatry 10 , 238 (2020)
PL significantly increased ROS levels and protein glutathionylation with a concomitant elevation in Nrf-2 expression, thus inducing the redox imbalance to kill two human colon cancer cell lines with mutant p53, HT29 and SW620 (Lee et al., 2015)
At the time it was an orphan receptor - a lock with no known key, since ghrelin, the body's own molecule that fits it, was not discovered until 1999
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