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Rutin protects hair cells and spiral ganglion neurons from cisplatin-induced ototoxicity by reducing ROS production after cisplatin exposure, activating PI3K/AKT signalling and inhibiting the JNK/p38/MAPK signalling pathway (Zheng et al., 2022)
In the same research, it also reduced markers of apoptosis (programmed cell death) in those cells, keeping them alive and functional longer
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S -nitrosylation is a key redox-based modification in plants and a pivotal mechanism to convey NO bioactivity
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