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doi: 10.1016/s0140-6736(16)30054-x 21 BrayGAKimKKWildingJPH

Biotechnology Progress, 34 (3), 659670

Saudi Arabia carries one of the highest diabetes burdens globally over 18% adult prevalence Treatment adherence remains a critical challenge, particularly around insulin initiation Reducing the annual injection burden from 365 to 52 is not a minor convenience it is a clinical differentiator For millions living with T2DM, daily injections remain one of the most significant barriers to insulin initiation and long-term adherence

ESG reduces stomach size without surgery GLP-1 medications help control appetite and metabolism Combining both approaches may improve weight-loss outcomes Medical supervision helps maintain long-term results Endoscopic Sleeve Gastroplasty (ESG) is a minimally invasive procedure that reduces stomach capacity using an endoscope inserted through the mouth