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These changes appear alongside improved lipid patterns, allowing researchers to observe measurable cardiovascular shifts that align with reduced metabolic strain under controlled study conditions
In SURMOUNT-1, published in NEJM in 2022, tirzepatide at the 15 mg weekly dose produced a mean placebo-adjusted body weight reduction of 17.8% at 72 weeks in adults with obesity (Jastreboff et al., NEJM, 2022)
For the appropriate patient, the barrier is most often the monthly copays and costs without insurance coverage
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