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This hormone plays crucial roles in postprandial glucose regulation by slowing gastric emptying, promoting satiety through central nervous system signaling, and modulating glucagon secretion

In addition, semaglutide has been shown to have greater appetite suppressive effects than liraglutide in overweight individuals and so may also be better at suppressing hyperphagia in lipodystrophy ( Another key potential advantage of GLP-1R agonists for lipodystrophy patients is the availability of both long acting and oral GLP-1R agonists ( Despite clear advantages to GLP-1R agonist use in lipodystrophy presented here, some patients with lipodystrophy also develop pancreatitis

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