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Intermittent claudication in peripheral arterial disease In peripheral arterial disease, atherosclerosis of the arteries that supply the lower extremities may diminish blood flow to the point that the metabolic needs of exercising muscles are not sufficiently met, thereby leading to ischemic leg or hip pain known as claudication (see the page on Intermittent Claudication in Peripheral Arterial Disease) (63)
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Contact your healthcare provider promptly if you experience: Severe or persistent abdominal pain , particularly if radiating to the back or accompanied by vomiting, as this may indicate pancreatitis (a rare but serious side effect) and requires urgent medical attention (call NHS 111, visit A&E, or call 999 if severe) Signs of gallbladder problems , including pain in the upper right abdomen, fever, or yellowing of skin or eyes (jaundice requires urgent assessment) Persistent nausea or vomiting that prevents adequate food or fluid intake, risking dehydration Symptoms of hypoglycaemia (if you have type 2 diabetes and take other glucose-lowering medications), such as shakiness, confusion, or excessive sweating Unexplained changes in bowel habits lasting more than a few days Difficulty swallowing or persistent heartburn , which may indicate delayed gastric emptying If you have type 2 diabetes, report any new or worsening visual symptoms promptly, as semaglutide may be associated with diabetic retinopathy complications
The kinetics of the metal release from CuProtein complex was also studied to ensure that the equilibrium was reached
