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The rationale (higher local drug concentration near the lesion) is plausible but unproven in humans
Wegovy became even more popular than drugmakers expected (including among people who are not medically eligible), causing a shortage
For example, a subject lost 6 kg in 3 months and another lost 2 kg over the subsequent 3 months on exenatide LAR 2 mg/week
This level of sustained weight reduction provides a powerful opportunity to reset metabolic health, allowing patients to both begin losing weight quickly and achieve a considerable total reduction over time
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