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Even human therapeutic monoclonals antibodies (such as Lanadelumab and garadacimab, both of the two authorized therapeutic monoclonal antibody with hereditary angioedema indication) are potentially immunogenic, since they contain unique amino-acid sequences in their antigen-binding hypervariable region (CDR) in high dose

2017;64:3637 Takeda A, Irahara A, Nakano A, et al

Most approaches to seasonal discomfort focus on blocking histamine after it's already flooding your system

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