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North Carolina Department of Health and Human Services
The demonstration of cardiorenal benefits with SGLT2i in clinical trials both for participants with CKD and type 2 diabetes and for those without [23,24,25] and the updated 2022 KDIGO guidelines recommending SGLT2i as first-line therapy for patients with CKD and type 2 diabetes regardless of glycemic control [6] have likely driven a shift toward their broader use for preventive cardiorenal protection and earlier implementation for patients with type 2 diabetes
However, there are certain situations where supplementation may warrant additional caution or a conversation with a healthcare provider before use
Independent testing of seized products has repeatedly found wrong active ingredients, contaminated material, and dose strengths that vary by tenfold from what the label claims
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