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Although ATRA itself doesnt act directly as an antioxidant, it functions as a potent transcriptional regulator that influences genes critical for oxidative stress responses
They require people to attempt to overcome a basic human instinct
Indeed, the increased thrombotic risk caused by hyperhomocysteinemia, recently reviewed by D'Angelo and Selhub (1997), seems to be independent of the conventional risk factors including protein C, protein S, and antithrombin III deficiencies
The HQ hydroxyl group is oriented towards ZnA, and its benzyl ring is stabilized through hydrophobic interactions with His208, similar to tyrosine substrates (Fig
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