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Limitations of Current Research Many studies are preclinical Human mechanistic trials remain limited Microbiome responses vary individually Diet, sleep, stress, and medications influence outcomes GLP-1 regulation is multi-factorial The microbiome is one variable within a complex endocrine network
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Table 1 Randomized controlled trials of tirzepatide in obese patients
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GahlWABernardiniIFinkelsteinJDTangermanAMartinJJBlomHJet alTranssulfuration in an adult with hepatic methionine adenosyltransferase deficiency
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Nature 441, 885889
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