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The SELECT trial for semaglutide showed a 20% reduction in major cardiovascular events over a mean 3.3 years in people with obesity and established cardiovascular disease
It is quickly converted by the liver into yet another little-studied chemical called TMAO that gets into the blood and increases the risk of heart disease. [Gina Kolata, New York Times 4/7/13] This article received a lot of attention, so I was asked by readers and friends to comment on it
Practical Considerations Dosage : The sleep study used 400mg daily (200mg twice daily) in children
Numerous studies have shown that this medication also has benefits beyond its glycemic effects, including cardioprotective and anti-hypertensive effects
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