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There are few if any medicines without side effects, and semaglutide is no different
At a systemic level, semaglutide significantly reduced circulating levels of numerous inflammatory and pro-fibrotic proteins, including master regulators of fibrosis such as IL-11 which is the dominant transcriptional response to TGF1 exposure and required for its pro-fibrotic effect 63
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One important distinction: tirzepatide consistently produces greater percentage weight loss than semaglutide in head-to-head comparisons
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