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This results in lower calorie intake and, consequently, weight loss
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Once internalized, the acidic pH of endosomes and lysosomes triggers protonation of chitosan's amine groups (pKa ~ 6.5), causing osmotic swelling and membrane disruption that facilitates escape of DOX into the cytoplasm and nucleus which corresponds to a phenomenon known as the proton-sponge effect [89, 90]
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